Can Depression Make You Sick? 8 Physical Symptoms

Jennifer E. Engen

Depression is a mental health condition that causes sadness and low mood. We associate symptoms such as feeling down and losing interest in activities with depression, but depression can come with a host of physical symptoms as well.

Read on to learn more about the ways depression can affect people physically.

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What Is Depression?

Depression is a mental health condition that affects how well a person is able to function in daily life. Biochemistry, genetics, personality, and environmental factors are believed to play a role in its development.

People with major depressive disorder experience symptoms that greatly affect their previous level of functioning and last at least two weeks. Many of these symptoms are mental, such as feeling sad or having trouble concentrating, but depression can also manifest physically.

Physical Symptoms of Depression

Depression is associated with a wide array of physical symptoms.

Fatigue or Low Energy

Fatigue is a very common symptom of major depressive disorder, affecting over 90% of people with the condition.

Fatigue can be divided into three subcategories:

  • Physical: Symptoms include tiredness, decreased activity, low energy, reduced physical endurance, requiring more effort to do physical tasks, general weakness or slowness, and poor quality sleep.
  • Cognitive: Symptoms include difficulty concentrating, decreased attention, reduced mental endurance, and slowed thinking.
  • Emotional: Symptoms include feeling less motivated, apathy, decreased interest, feeling overwhelmed, feeling bored, and feeling low.

These feelings of exhaustion may be related to:

  • The psychological toll of depression
  • Changes in the levels of neurotransmitters dopamine, norepinephrine, and serotonin affecting energy levels
  • Sleep difficulties commonly associated with depression

Fatigue can also be a side effect of some medications used to treat depression, such as tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs).


Unexplained aches and pains, including headaches, back pain, joint pain, and muscle pain, commonly occur with depression. These pains can range from mild to severe enough to impact a person’s functioning. The connection is thought to be because depression and pain share the same nerve pathways and brain chemicals.

Some studies have shown that the worse the physical pain symptoms, the more severe the depression is.

A small study of 54 people, completed in 2015, found that people with major depressive disorder had a lower pain threshold and pain tolerance than their healthy counterparts.

A larger 2017 study suggests that people experiencing depression are approximately 60% more likely to develop back pain in their lifetime than those who do not experience depression. In addition to depression increasing the likelihood of back pain, persistent low back pain was also shown to increase the risk of developing depressive symptoms.

Sleep Difficulties

Many people with depression report that they experience poor quality sleep. Depression can cause sleep disturbances such as:

  • Difficulty falling asleep
  • Poor quality sleep
  • Getting fewer hours of sleep
  • Waking more during the night
  • Daytime tiredness
  • In some cases, very early morning awakening without being able to fall back to sleep

The lack of good quality sleep can impact other depression symptoms such as difficulty concentrating and pain.

The parts of the brain associated with depression are also involved in the regulation of the circadian rhythm (sleep/wake cycle). People with depression can experience shifts in when they sleep, even if they are sleeping the same number of hours. For example, they may have difficulty falling asleep at night but be tired during the day.

Gastrointestinal Symptoms

Depression can cause digestive issues, such as:

The brain has a direct connection to the gastrointestinal tract, making the stomach and intestines sensitive to emotion. The digestive tract can also send signals to the brain. A stomachache may contribute to or be the result of depression, anxiety, or stress.

Cardiovascular Effects

Studies have shown that depression can increase the risk of cardiovascular disease, particularly for those who experience more severe depression symptoms.

This increased risk may be explained, at least in part, by lifestyle habits associated with depression. Certain lifestyle factors that can increase cardiovascular risk tend to be more common in people with depression, including:

  • Smoking
  • Alcohol and substance use
  • Physical inactivity
  • Poor nutrition

Psychomotor Symptoms

Depression can affect the way the body and mind work together to complete tasks.

Slowed psychomotor activity can affect:

  • Speech: A person’s speech may have more pauses, be quieter, have less articulation, be more monotonous, and involve delayed responses in conversations.
  • Eye movement: A person may have reduced eye contact or a fixed stare.
  • Facial movement: The person may appear to maintain a flat expression and not react to emotion.
  • Bodily movement: The body may move more slowly, and there may be difficulty with fine motor tasks such as writing, doing up buttons, or handling money. The person may feel “weighed down” when walking or changing positions, and have a slower reaction time. There may also be an increase in purposeless movement, such as difficulty sitting still, pacing, or fidgeting.

Changes in Appetite

Depression can cause appetite changes and weight loss or weight gain. Depression symptoms such as exhaustion can make meal planning and cooking more difficult. This may make it harder to maintain a nutritious diet.

Depression is also associated with changes to the hormone cortisol, which can affect stress levels. This may lead to “emotional eating,” in which a person eats in response to negative emotions. The foods people turn to when emotionally eating tend to be energy-dense and enjoyable to eat.

Reduced Sex Drive

While most people experience fluctuations in sex drive, some people with depression lose their desire for sex completely. This can be due to the lack of energy seen in depression, or the lack of desire to engage in activities a person once enjoyed.

Sexual dysfunction can be difficult or embarrassing to discuss, but if you are experiencing a severe decrease in sex drive that is affecting you or a partner, talk about it with your healthcare provider.

Psychological Symptoms of Depression

Some psychological symptoms of depression include:

  • Persistent low mood or sadness
  • Feelings of helplessness, guilt, and/or hopelessness
  • Irritability
  • Feeling “teary” or crying
  • Lack of motivation
  • Disinterest or lack of enjoyment in things
  • Difficulty making decisions
  • Thoughts of suicide or self-harm

How Are the Physical Symptoms of Depression Diagnosed?

A healthcare provider will likely do an exam and run tests to see if your symptoms may be caused by a physical condition, such as thyroid problems.

If a physical cause is ruled out, your provider will ask about your general health and family history, physical and mental symptoms, and other information that can help them make a diagnosis.

If depression is diagnosed, your healthcare provider will discuss ways in which to manage symptoms, including physical ones.

What Comes First?

Many of the physical symptoms associated with depression can either contribute to depression or be caused by depression. It can sometimes be difficult to tell which came first. Discuss your symptoms with your healthcare provider to find an accurate diagnosis and the most appropriate course of treatment.

When to See a Healthcare Provider

If you experience symptoms of depression—whether psychological, physical, or both—schedule an appointment with your healthcare provider.


Depression is a mental health condition characterized by sadness and low mood or energy. In addition to psychological symptoms, depression is associated with physical symptoms such as fatigue, gastrointestinal problems, and sleep problems. People experiencing physical symptoms should discuss them with their healthcare provider.

A Word From Verywell

The psychological symptoms of depression alone are challenging enough to live with, so the addition of physical symptoms can feel especially overwhelming. If symptoms of depression are making you feel unwell, it may help to know there are treatments available. Contact a healthcare provider or a mental health professional to discuss treatment.

Frequently Asked Questions

  • How can you help someone with depression?

    You can help someone with depression by offering patience, support, understanding, and help. Recognize that depression is an illness, not someone being “difficult.” Encourage them to seek professional help and support them in doing so.

  • What does depression feel like?

    Depression can have psychological symptoms, such as persistent feelings of sadness, irritability, a lack of motivation, and a loss of enjoyment. It can also have physical symptoms, such as fatigue, sleep difficulties, and gastrointestinal problems.

  • What is manic depression?

    Manic depression is a term that was once used for the condition now known as bipolar disorder. The hallmark of bipolar disorder is alternating periods between elevated moods and depressive moods, often in extremes.

  • How can you cope with depression?

    Getting a proper diagnosis is the first step in managing depression. From there, work with a healthcare provider or mental health professional to find a treatment plan suited to your needs.

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