The Neglected Role of Psychotherapy for Treatment-Resistant Depression

Jennifer E. Engen

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved over 40 years since the recognition that some patients minimally benefit from repeated antidepressant medication trials. No uniform definition exists for TRD (1–10). What constitutes TRD has unfortunately varied across settings and literature reviews, differing in defining trial adequacy, nonresponse, […]