Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study

Jennifer E. Engen

Summary Background Few studies investigated the mechanisms of treatment-resistant depression (TRD) leading to the worsened survival outcome, and economic evidence was mostly restricted to short follow-ups. We aimed to examine the association and potential mediators between TRD and all-cause mortality, and estimate a longer-term associated health resource utilisation pattern. Methods […]

Study shows clinical value of pharmacogenomic testing for patients with treatment-resistant depression

Jennifer E. Engen

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental Health- (CAMH-)led clinical study just published in the journal Translational Psychiatry. The 52-week double-blind study, comparing pharmacogenetic testing guided treatment to treatment as […]

Pharmacogenetic testing shows promise improving symptoms in patients with treatment-resistant depression — ScienceDaily

Jennifer E. Engen

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental Health- (CAMH-)led clinical study just published in the journal Translational Psychiatry. The 52-week double-blind study, comparing pharmacogenetic testing guided treatment to treatment as […]

The Neglected Role of Psychotherapy for Treatment-Resistant Depression

Jennifer E. Engen

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved over 40 years since the recognition that some patients minimally benefit from repeated antidepressant medication trials. No uniform definition exists for TRD (1–10). What constitutes TRD has unfortunately varied across settings and literature reviews, differing in defining trial adequacy, nonresponse, […]

What is treatment-resistant depression? New report calls for clearer definition to inform research and improve treatment.

Jennifer E. Engen

Newswise — A group of mental health experts from research, industry, regulatory bodies and with lived experience have proposed new agreed criteria to define the type of depression that current medications and therapies cannot treat effectively. The report aims to provide consistent definitions for future research, and especially for designing […]